Order blood cultures in clinically deteriorating patients, not just when fever or CRP is elevated. Fever timing doesn’t increase yield, and modern techniques detect bacteria regardless of symptoms. Proper blood volume is key—draw at least 2 sets (preferably 3) with 8–10 mL per bottle. A single-draw strategy is efficient and reduces patient discomfort. Avoid routine cultures for all fevers or low-risk infections; follow guidelines and use clinical judgment to guide testing.