New retrospective studies continue to claim that each hour delay in antibiotic administration significantly increases mortality in sepsis and septic shock, implying that any patient with a hint of sepsis should receive antibiotics immediately. However, both sepsis and septic shock can present with widely variable clinical features, making diagnosis challenging. This blog explores the current evidence regarding the time to antibiotic administration in sepsis and septic shock.

This article discusses 1) Why we don't have a good idea how to treat Stenotrophomonas maltophilia; 2) Whether S. maltophilia should always be treated by combination therapy; 3) What are the best ways to treat S. maltophilia