Why Avoiding Anaerobic Coverage in Sepsis Faces Limitations: a Critical Review
When no anaerobic cause of infection was suspected, antibiotics without anaerobic coverage were preferentially selected. With the latest edition of the Surviving Sepsis Campaign Guidelines introducing a similar recommendation for sepsis and septic shock (conditional recommendation, very low certainty of evidence) (1), there is an ideal opportunity to explore this further
9 hours ago7 min read
How Procalcitonin Can Guide Early Antibiotic Discontinuation
1) What is the evidence for using procalcitonin-guided algorithms in antibiotic discontinuation?
2) What are the main points of criticism against procalcitonin-guided algorithms?
3) How to implement a procalcitonin-guided algorithm in clinical practice?
Jun 266 min read
Procalcitonin in Clinical Practice: Should It Be in Your Diagnostic Toolkit?
1) What is the pathophysiological role of procalcitonin?
2) How good is procalcitonin in accurately guiding the initiation of antibiotics?
Apr 268 min read
Is Pseudomonas Pneumonia Truly Exceptional? Re-evaluating the Standard of Practice
1. How to empirically treat Pseudomonas Pneumonia?
2. Should combination therapy be used in definitive treatment of Pseudomonas pneumonia?
3. Is there any evidence to treat Pseudomonas pneumonia longer than 7 days
Mar 198 min read
Postoperative fever: A Practical Guide to Assessment and Management
Postoperative fever, especially in the first few days after surgery, is often benign and does not require the same aggressive approach. Multiple studies indicate that it is frequently over-investigated and over-treated. This blog post attempts to give guidance on how to deal with postoperative fever.
Feb 175 min read